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"The 4mg dose efficacy data for retatrutide are compelling enough that first-line positioning cannot be dismissed," Citi analysts wrote in a note

In June 2021, the FDA approved Wegovy as a weight loss medication for adults battling obesity and those overweight due to specific health issues

While this was the most transparent she has been about her weight-loss journey, this wasn't the first time Clarkson had spoken about her health and size

Indeed, the chronotropic effects of GLP-1RAs may be deleterious in HF patients, with higher sympathetic activity contributing to morbidity and mortality [20]

Heart Rate Effects Heart rate increases were noted in some retatrutide participants

When to reduce your dose Reduce if you have escalated and experienced persistent vomiting across more than four days