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The results showed that patients with FMS had globally-reduced pain thresh- olds, that is, they perceived pain at lowered thresholds of pressure over both the control points and the TePs.19,20 Lastly, the data comparing groups of healthy controls and patients with FMS clearly showed that the FMS group had an across-the-board decreased pain threshold and greater self-rated disability level.21 Another interesting hypothesis comes from Crofford,22 who reviews the role of the hypothalamic-pituitary-adrenal stress axis in the development of FMS

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