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GLP-1, Metformin and rapamycin : three names that keep cropping up in the modern longevity conversation

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In a placebo-controlled trial conducted on patients having pre-existing coronary artery disease with preserved left ventricular function, increase in GLP-1 levels caused by DPP-4 inhibition resulted in improvement of global and regional left ventricular function and amelioration of post-ischemic stunning [70]

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Preclinical studies have identified GLP-1 receptors throughout the gastrointestinal tract, including on enteroendocrine cells, neurons, and immune cells

The most common side effects are gastrointestinal: nausea, fullness, constipation, diarrhea, reflux, and reduced appetite