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K., Motrapu M., et al

Moving ahead, Phase 3 clinical trials will assess its efficacy and tolerability for chronic weight management, obstructive sleep apnea, and knee osteoarthritis in people with obesity and overweight

The weight-loss results at 48-weeks found with the 12 mg retatrutide group an average weight reduction of 24.2% was achieved, while the placebo group only saw a 2.1% change

This dual mechanism explains the unprecedented weight loss numbers from clinical trials

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"To maintain vaginal health while using GLP-1 agonists, I recommend staying well-hydrated, using a vaginal probiotic and considering the use of vaginal moisturizers if experiencing dryness," Bone said