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Another study supported that the stress of hyperglycemia induced the accumulation of advanced glycation end (AGE) products, which led to an increase in reactive oxygen species, the activation of inflammatory pathways and reduction of cardiac energy efficiency [42]

During insulin resistance (IR), glucose metabolism converges in mitochondria via insulin signalling causing diabetes progression [57]

Segn el estudio SELECT, Wegovy contribuye indirectamente a una mejor salud cardiovascular gracias a la prdida de peso y a la disminucin de enfermedades relacionadas con el sobrepeso como hipertensin, diabetes, etc

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[27] demonstrated that GIP receptor neurons differ in their connectivity, transcriptomic profile, peripheral accessibility, and appetite-controlling mechanisms with vast heterogeneity of the central GIP receptor signalling axis and further studies are needed to clarify the effects of GIP pharmacology on feeding behavior