tirzepatide drowsy for Weight Loss Does Tirzepatide Make You Tired?

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Orskov, C

The molecule itself is fragile compared to small-molecule medications

In a cerebrospinal fluid (CSF) substudy, participants receiving semaglutide exhibited modest yet statistically significant reductions (in the range of 10% or less) in several key biomarkers associated with Alzheimers disease (AD) pathology and neurodegeneration, including phosphorylated tau181 (p-tau181), phosphorylated tau217 (p-tau217), total tau, and the neuroinflammatory marker YKL-40 levels

While both tirzepatide and semaglutide cause GI side effects , the specific profile differs, and some patients who do not tolerate one may tolerate the other