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J Biol Chem 289(33):2324623255 Kim J-H, Park G-Y, Bang SY, Park SY, Bae S-K, Kim Y (2014b) Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4

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Baseline WOMAC pain score: 6.0 Reduction at 80 weeks: 4.3 points Percent reduction: 73.1% A 73% drop in joint-pain scores is the kind of effect usually associated with a dedicated analgesic or joint intervention, not a metabolic drug