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Description
Participants began on a low starting dose and underwent gradual escalation at defined intervals to minimise gastrointestinal side effects

Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes

Expert Rev Clin Pharmacol

Gut 40 , 597601 (1997)

However, the GH response may attenuate with continuous daily use (tachyphylaxis), which is why titration strategies and periodic breaks are often incorporated [4][7]

Rates of diabetic ketoacidosis (DKA) and hypoglycemia were similar between groups
