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In one 2023 trial, participants receiving higher doses lost more than 20% of their body weight over 48 weeks

While these medications play a role in metabolic care, they also introduce significant clinical considerations, particularly for individuals with current or past eating disorders

On the other hand, Timper et al

Cardiovascular exercise supports overall health and can increase the caloric deficit, but it should not come at the expense of resistance training

Serious Risks and Contraindications While rare, GLP-1 medications carry risks that require medical supervision: Thyroid C-cell tumors - Animal studies showed an increased risk of medullary thyroid carcinoma in rodents