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In fact, it often produces worse outcomes because severe nausea leads to dehydration, nutritional deficiency, and sometimes medication discontinuation
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Inhibition of incretin degradation and prolonged action of GLP-1 and GIP: As DPP-4 inhibitors, they work by elevating the amounts of incretin hormones in the body
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Given the natural fluctuations in hormone levels and the intricate rhythms of human physiology throughout the day and over a persons lifetime, there is concern about the uncertain health ramifications of sustained elevation of incretin activity over decades of treatment
10.1001/jama.289.2.187 42 FrankA.BrownL
