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In clinical studies, participants taking Retatrutide experienced up to 24% weight loss over 48 weeks, more than observed with current GLP-1 treatments

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GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and GIP/GLP-1 dual agonists (tirzepatide) modulate appetite regulation, satiety signaling, and gastric emptying

The clinical evidence on GLP-1s in that context is blunt

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By improving cholesterol levels, tirzepatide may help reduce the risk of cardiovascular events, such as heart attacks and strokes