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Description
GLP-1 receptor agonists are likely to assume a growing role to treat obesity

Clinical trials have demonstrated that semaglutide produces progressive improvements over time
Regul Pept 1999, 85: 924
However, this does not definitively exclude the possibility that some patients may experience back pain during therapy

The primary objective in AWARD-5 was to establish that dulaglutide was noninferior to sitagliptin in its ability to reduce HbA 1c from baseline through 52 weeks

For most patients, the metabolic and cardiovascular benefits of GLP-1 medications outweigh the modest bone risk
