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Trial registration NCT02723110, NCT02465515 and NCT01144338.

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This study is based on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare products Regulatory Agency

New Acosta Group research reveals that most consumers are using GLP-1 medications for relatively short durations, with 90% of former users stopping within the first year.

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Results The levels of GLP-1R decreased significantly in the knees of OA rats, accompanied by the downregulation of PKA /CREB signals and upregulation of inflammation-related proteins