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Nausea: Both GLP-1 medications and, less commonly, HRT can cause nausea

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When taking GLP-1 medications, its advisable to steer clear of high-fat foods, sugary treats, and large meals

Selective post-translational proteolysis of proglucagon by prohormone convertases 1 and 2 results in the tissue-specific production of a number of biologically-active fragments

This is suggestive of GLP-1 action on the brain's reward circuitry - the interconnected regions, such as the striatum, orbitofrontal cortex, amygdala, and midbrain dopamine centers, that drive the pleasure in and motivation for food