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Withdrawal effects from GLP-1 medications include increased hunger, food preoccupation, and in some cases, rapid weight regain of 5-10% within the first few months off treatment

Jensen L, Helleberg H, Roffel A, et al

71.2 lbs on average) Retatrutide 9mg: 26.4% body weight reduction Tirzepatide/Zepbound (Phase 3 comparison, not head-to-head): ~20.9% Semaglutide/Wegovy (Phase 3 comparison, not head-to-head): ~14.9% Placebo: ~2.1% Note: These figures come from separate Phase 3 trials and are not direct head-to-head comparisons

Many injection pens are single-use and pre-measured, which may reduce the risk of error

Wilding et al., NEJM, 2021

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