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To Issue 172 C itation: Lock D, Rethinking GLP-1 Delivery Devices: Designing for Users Beyond Diabetes

doi: 10.7554/elife.63671

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The JAK/STAT signaling pathway: from bench to clinic
But efficacy is only half the story
Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose
