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6 Multi-agonist strategies are increasingly being studied, some of which include dual GLP-1/GIP agonists like tirzepatide and triple agonists that target GLP-1, GIP, and glucagon-like retatrutide

Cognitive decline tracks with vascular health, metabolic health, neuroinflammation, and protein aggregation, and GLP-1 receptor agonists touch all four

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Additionally, internalized receptors and GPCR:-arrestin complexes can continue to signal from the endosome, with this process potentially engaging alternative signalling cascades (Willard et al., 2020)

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GLP-1s dramatically reduce appetite and increase satiety
