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First, the expression of GLP-1R remains controversial in many types of cells and tissues due to the lack of specific antibody against GLP-1R

Significant improvements were observed in comorbidities, including reductions in obstructive sleep apnea ( 30%), hypertension ( 40%), and arthralgia ( 56.5%)

In 2023, the FDA and European Medicines Agency (EMA) began investigating a possible relationship after receiving reports of suicidal thoughts while patients were taking the drugs

Starting at a low dose and increasing slowly allows the digestive system to adjust, minimizing discomfort and improving long-term adherence to treatment