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Although studies have confirmed that GLP-1RAs do have a certain regulatory effect on the proliferation and apoptosis of tumor cells, the application of GLP-1RAs in tumor-related diseases is not currently its main indication, but GLP-1RAs can have a protective effect on the heart, kidney and other organs through their anti-inflammatory, antihypertensive, and lipid-regulating effects

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Still, genetics explains only a portion of treatment heterogeneity, and routine pharmacogenomic screening is not yet ready for widespread clinical use, he added

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In obese mice, the GIPR/GLP-1R co-agonist produced greater decreases in body weight and food intake, as well as improved glycemic and lipid outcomes, when compared to equal doses of either exendin-4 or liraglutide