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Glucagon is synthesized and released from pancreatic alpha cells and from intestinal L cells of the ileum and colon
Batsis JA, Apolzan JW, Bagley PJ, et al
In contrast, the expression of GLP-1 mRNA in the colon tissues of mice in the model group decreased, and the content of GLP-1 in serum decreased
Individuals with pre-existing diabetic retinopathy, long diabetes duration (typically over 10 years), poor prior glycaemic control, and those experiencing rapid HbA1c reductions face the highest risk
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