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This article reviews current evidence, evaluates pharmacological and mechanistic safety profiles, summarizes recent cohort studies, and discusses clinical management strategies for preconception counselling and inadvertent exposure

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2,32,33 POTENTIAL FUTURE THERAPIES Given the elevated GLP-1 levels and robust insulin response to glucose observed in PGBH, blocking GLP-1 may provide clinical benefit

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New preliminary Noom data show that members who used Nooms GLP-1 programs maintained the vast majority of their weight loss after stopping medication, with modeled estimates showing less than 2% body weight regain up to 12 months after discontinuation