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This tool evaluates potential sources of bias across twelve domains: Domain 1: Clearly stated aims/objectives

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Injectable Wegovy: Average weight loss: about 15% of starting body weight over 68 weeks Studied in the STEP 1 trial with over 1,900 adult participants Participants combined the injection with a reduced-calorie diet and increased physical activity Oral Wegovy pill: Average weight loss: about 14% of starting body weight over 64 weeks Studied in a separate 205-person clinical trial Similar lifestyle requirements were applied to both clinical studies The difference between the 2 studies is small, but they were not a direct head-to-head comparison

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Maintaining a stable storage environment helps ensure the medication remains safe and effective for the recommended period