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N Engl J Med 377(3):300301

Renal Acute Kidney Injury Acute kidney injury is an uncommon but recognized complication of GLP-1 receptor agonists

a Values represent pooled placebo-adjusted mean differences (95% confidence interval)

GLP-1 RECEPTOR AGONISTS GLP-1 receptor agonists enhance insulin secretion, delay gastric emptying, promote lipolysis, and stimulate weight loss, indirectly improving hepatic inflammation and fibrosis

Metabolic messengers: glucagon-like peptide 1

Due to long half-lives, agents like semaglutide and tirzepatide must be discontinued at least 35 days before conception
