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GLP-1 stimulation of adipose tissue monocytes increases IL-6 signaling in adipocytes, leading to increased UCP-1 expression and glucose metabolism [112]

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We have noticed a similar upward trend in utilization and spend for GLP-1s across our book of business, with plan drug spend for Wegovy alone increasing over 500% between 2022 and 2023

Ozempic and similar GLP-1 medications have transformed weight management, yet most health insurance companies classify them as cosmetic treatments when prescribed for weight loss alone

GLP-1/GLP-1R functions in different knee joint tissues OA is a whole-joint degenerative disease, and pathological changes seen in OA include degradation of cartilage, synovial inflammation and thickening of subchondral bone with osteophyte formation, associated with symptoms such as pain and stiffness