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Patients taking insulin or sulfonylureas should be particularly vigilant about hypoglycemia risk if nausea reduces food intake, and may need adjustment of these medications

Interestingly, some evidence suggests that weight loss achieved through GLP-1 therapy before conception may improve fertility outcomes in people with obesity-related ovulation problems, though individual results vary

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Administration of a GLP-1 RA may decrease glucagon secretion and hepatic gluconeogenesis

Consider thermal socks, base layers, or even fingerless gloves indoors if needed