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All p values were two-tailed and level of significance was set at 0.05

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Norepinephrine reuptake inhibition: Increases metabolic rate (thermogenesis) Enhances fat oxidation Suppresses appetite centrally Increases energy expenditure Also increases heart rate and blood pressure (side effects) 3

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Bethel MA, Patel RA, Merrill P, Lokhnygina Y, Buse JB, Mentz RJ, Pagidipati NJ, Chan JC, Gustavson SM, Iqbal N, Maggioni AP, Ohman P, Poulter NR, Ramachandran A, Zinman B, Hernandez AF, Holman RR

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Compounded semaglutide is prepared by state-licensed U.S

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