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Awareness of weight loss tablets is still relatively low among the wider public, but interest is likely to grow quickly as these treatments become available in the UK

N Engl J Med 2025;393:1796-1806 [9] Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial, December 2025: Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial | Eli Lilly and Company [10] Fourth High-level Meeting of the UN General Assembly on the prevention and control of NCDs and the promotion of mental health and wellbeing (HLM4), September 2025: [11] Thousands of patients from Scotlands poorest areas to benefit from landmark UK government-funded obesity study, November 2025: Thousands of patients from Scotlands poorest areas to benefit from landmark UK government-funded obesity study - GOV.UK [12] Non-Traditional Channels: The Compounded GLP-1 Market

Orforglipron 36 mg was superior to semaglutide 14mg with respect to mean change in glycated haemoglobin (HbA1c) in patients with Type 2 diabetes inadequately controlled with metformin over 52 weeks

doi: 10.1161/CIRCULATIONAHA.112.122408

GLP-1 RA therapies have also been noted to have heart and kidney protective effects, although benefits in the kidney at this time appear to be isolated to preventing the progression of proteinuria, and CV benefits appear to be primarily anti-atherosclerotic rather than on the basis of preventing HHF with SGLT2 inhibitors

Economic costs of obesity: a systematic review
