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Indirect benefits may arise from weight reduction and improved metabolic health

Mehrabian, S

In preclinical models of NASH, the administration of AC3174, an analogue of exenatide, led to significant reductions in body weight, LFC, and levels of plasma alanine aminotransferase (ALT) and triglyceride [24]

Effects of Liraglutide compared with placebo on events of acute gallbladder or Biliary Disease in patients with Type 2 Diabetes at high risk for cardiovascular Events in the LEADER randomized trial

n=176) *Values are Mean SD Type 1 Diabetes Adult (see Table 6) Two open-label, parallel design studies (6 weeks [n=29] and 16 weeks [n=118]) compared NOVOLOG to buffered regular human insulin (Velosulin) in adults with type 1 diabetes receiving a subcutaneous infusion with an external insulin pump

While these findings provide biological plausibility for a direct cardiac mechanism, they do not demonstrate functional receptor activity or confirm that semaglutide acts directly on these cells