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Regarding cardiovascular effects , stimulant medications may increase heart rate and blood pressure, while GLP-1 receptor agonists like Wegovy typically cause a modest increase in heart rate but may slightly reduce blood pressure
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For example, in August 2025, the Ozempic MDL judge entered an order saying that patients filing a gastroparesis claim must prove that their doctors used a gastric emptying study to diagnose them with gastroparesis

Many patients tolerate an adjustment period where nausea and mild bloating occur but resolve as the body adapts

In the landmark SURMOUNT trials , participants using the highest dose of tirzepatide (15 mg) achieved an average weight loss of approximately 2022% of their initial body weight over 72 weeks

A study by Walter-Sack, I., et al
