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In the Phase 2 trial published in the New England Journal of Medicine, the retatrutide dosage chart showed clear dose-response results

One of the most obvious factors is baseline body weight

That reduction occurred within 48 weeks and exceeded the results of any other drug tested for that condition (Sanyal et al., NEJM 2024)

These include: Severe stomach pain Ongoing vomiting Severe dehydration Allergic reactions like rashes or trouble breathing Symptoms of acute kidney injury, such as decreased urination If these occur, seek immediate medical care

Key Takeaways: Benefits: Lower risk of major cardiovascular events (up to 40% in some studies), improved blood sugar, and weight loss