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Serious risks reported with GLP-1 therapy include pancreatitis, gallbladder problems, low blood sugar (particularly alongside other diabetes medicines), kidney issues from dehydration, and allergic reactions

Severe or persistent abdominal pain, especially if radiating to the back and accompanied by nausea or vomiting, may indicate acute pancreatitisa serious adverse effect requiring emergency evaluation

Xiao N, Wang Z, Huang Y, Daneshgari F, Liu G (2013) Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes

Semaglutide exhibits high bioavailability with subcutaneous administration, achieving slow and sustained absorption due to strong albumin binding, which prolongs its half-life to approximately one week[9]

Third, the large sample size in the propensity-matched analyses resulted in narrower CIs, demonstrating higher precision

Semaglutide was notably associated with high risks of ischemic optic neuropathy and diabetic retinopathy