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Description
When switching between GLP1RAs, transient GI AEs are expected and can be reduced by slow uptitration, including use of intermediary doses, and advising patients to reduce portion sizes and fat intake

Despite strong clinical evidence supporting the effectiveness of GLP-1 therapies for weight loss, coverage remains inconsistent and often restrictive

But with type 2 diabetes, your body cant effectively use the insulin it makes

As the GLP-1 category enters its next chapter, marketing around the drugs is also maturing

doi: 10.1016/j.molmet.2021.101180

In contrast to the classically secreted proteins, the signal peptide is not cleaved off, but serves as a membrane anchor
