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Abstract Recent large clinical trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, with the aim of verifying cardiovascular safety, have revealed that these medications have a preventative advantage on adverse cardiovascular outcomes, including worsening of heart failure and deterioration of nephropathy, in patients with type 2 diabetes (T2D)

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At the molecular level, testosterone influences key anabolic pathways, including activation of the mechanistic target of rapamycin (mTOR) complex and downstream translational machinery

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