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Powell, C

These drugs also appear to have major pleiotropic effects in CV risk reduction, (STEP trials , SELECT trial, STEP HFpEF, SCRIBE, SUMMIT, SURMOUNT-MMO (completion 2027)) reversal of metabolic dysfunctionassociated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (SYNERGY NASH MASH), and non-progression if not reversal of chronic kidney disease (CKD) (FLOW trial)

Most clinical trials for these weight loss medications have excluded patients with significant gastrointestinal diseases, including active IBD

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Dermatology and Therapy, 10 (6), 1345