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Meat hydrolysate stimulates GLP-1 secretion from NCI-H716 cells, an effect that is not related to changes in proglucagon expression [253]

Nutritional considerations for off-label use remain unclear and, given the rapidly growing public use of GLP-1s, are an important area of needed research

Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22

The weight loss industry has been extremely commercialized, and there are a lot of snake oil salesmen out there

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However, it is essential to validate the clinical significance and sustainability of the possible benefits in diverse population groups who may not necessarily aim for weight loss through carefully designed and sufficiently powered studies