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Considering this finding, we grouped patients with PBH according to their previous history of cholecystectomy and assessed the dynamics of glucose, insulin and c-peptide during MMTT
The mechanisms that drive enteroendocrine release of these gut peptides into the blood stream are multifactorial and include responses to direct nutrient stimulation, intracellular metabolism, or neuroendocrine mechanisms [see Psichas, et al

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The key secondary endpoints demonstrated significant reductions in atherogenic lipid levels and liver stiffness over 52 weeks in the 80 mg and 100 mg resmetirom
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