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In animal research, increasing plasma adiponectin levels through pharmacological or genetic means has shown to alleviate obesity-induced endothelial dysfunction, hypertension, atherosclerosis, myocardial infarction, and diabetic cardiomyopathy
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They also spread across different tissues of the body and in the skin
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In control experiments, both native GLP1 and GLP1(936) have been shown to produce vasodilation and increase cGMP release from isolated, preconstricted blood vessels when tested ex vivo
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