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Reduced risks were noted for cancers of the digestive (HR 0.81), respiratory (HR 0.66), and female genital (HR 0.87) systems

Just two weeks later, on 1 April 2026, the FDA approved Foundayo, Eli Lillys brand name for orforglipron, making it the first small-molecule, non-peptide oral GLP-1 receptor agonist approved for chronic weight management

In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) has issued warnings about severe dehydration in people taking these injections

Borderline diabetes is often reversed by gastric bypass

Dry mouth is not just uncomfortable

But most products marketed to GLP-1 users haven't had to meet a defined regulatory standard for that claim