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Semaglutide was originally developed for type 2 diabetes, but clinical evidence now supports its use for chronic weight management in people without diabetes who have overweight or obesity

While the effects of GLP-1RAs have been extensively studied in the context of diet-induced obesity, their impact on physiology in other nutritional contexts have been less explored

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Glucagon-like peptide 1 (GLP1) receptor agonists reduce the rate of major adverse cardiovascular events in people with type 2 diabetes mellitus

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These uses are off label