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Authors relationships and activities A-MC, AJC and LBK are employees of Novo Nordisk A/S

Semaglutide carries a specific warning about potential worsening of diabetic retinopathy in patients with pre-existing retinopathy, particularly with rapid improvement in glucose control

Not everyone will experience fatigue with semaglutide

Cold Turkey Abruptly stopping semaglutide triggers an immediate rebound in appetite and hunger, similar to suddenly stopping other appetite-suppressing medications

Personalized Treatment: Finding the Right GLP-1 Medication Not all GLP-1 medications work the same way for everyone, which is why its important to find the right one based on your individual health needs and goals

Fatigue is common in the first weeks, often related to reduced caloric intake as appetite suppression takes effect