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Description
En este subanlisis, semaglutida demostr beneficios renales en personas con obesidad y riesgo cardiovascular alto, pero sin DM2, reduciendo de manera significativa los eventos adversos renales (semaglutida [1,8%] frente a placebo [2,2%]) y desacelerando la cada del filtrado glomerular (semaglutida 0,78 frente a placebo 1,17ml/min/1,73m2/ao)

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To generate mutations at the APTF-2 target site in the glp-1 promoter we injected the following mix: Cas9 protein (5 g), tracrRNA (0.4 g/l), crRNA (aatgggcggagtatgccacc) (0.4 g/l), ssDNA oligo repair donor (1 g/l), myo-2::mCherry plasmid (4 ng/l) and brought to a 20 l volume with nuclease-free water

The SURPASS-PEDS trial demonstrated safety and efficacy in this younger population
What Caused The Shortage

Evidence suggests it can effectively reduce weight and improve metabolic parameters in such cases, with its weekly dosing and tolerable side effects making it a good option, particularly for patients unresponsive to metformin [80]
