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While taking a GLP-1 agonist, some foods can worsen side effects or undermine your results

Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes

et al., 2025) confirm that lean mass loss is a significant side effect of GLP-1 treatment

This context supports a more personalized cost-benefit conversation with your provider, regardless of which option you choose

Setting realistic expectations is crucial: weight loss is gradual, with clinical trials showing approximately 15% weight reduction with semaglutide 2.4 mg at 68 weeks and up to 21% with tirzepatide at 72 weeks, though individual responses vary considerably

They produce weight loss unlike anything we've seen before, and the more we study them, the longer the list of things they seem to help