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A class action lawsuit landed in California's Northern District on June 25, 2025

In controlled trials, subjects treated with GLP1-S displayed lower glucose area under the curve (AUC) during standardized meal tests, pointing to coordinated effects on pancreatic, hepatic, and gastrointestinal functions

Hence, it is unclear whether the lack of CV benefit with oral semaglutide is attributed to its formulation or secondary to selection bias

[See Clinical Pharmacology (12.3).] Add-on Combination Therapy with Metformin A total of 701 patients with type 2 diabetes participated in a 24-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of JANUVIA in combination with metformin

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