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Gastrointestinal side effects may increase dehydration risk in hot weather, requiring careful fluid management

However, compounded drugs are not FDA-approved and have not undergone the rigorous clinical testing required for approval

Supply disruptions happen in the compounding pharmacy world, whether from ingredient shortages, regulatory changes, or quality control holds

One person might think GLP-1 is a specific drug

Both medications also improve cardiometabolic markers such as blood pressure and cholesterol, though the magnitude of improvement varies between individuals

Importantly, these effects were not accompanied by reductions in locomotor activity or food reinforcement, suggesting specificity for opioid-directed behavior