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Triple-hormone-receptor agonist retatrutide for obesityA phase 2 trial

Food stays in the stomach longer, and the usual signals that prompt hunger and digestion are suppressed

Valencia-Rincn et al

It can form what we call a bezoar, or a fiber brick, in the gut, leading to painful bloating and gas

However, other countries with no specific BMI requirement also register low use of GLP-1 RAs, suggesting that the cost limitation could not be a major obstacle in its wider uptake [18, 42]

If you plateau or experience persistent appetite challenges despite these efforts, compounded semaglutide therapy addresses the physiological limitation directly