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Defining inflammatory cell States in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

GLP-1 microdosers are chasing longevity

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GLP-1 was initially discovered for its ability to enhance glucose-stimulated insulin secretion (GSIS) (Kreymann et al., 1987

[DOI] [PubMed] [Google Scholar] 189.Wycherley T.P., Moran L.J., Clifton P.M., Noakes M., Brinkworth G.D

The EM structure of Tirzepatide bound to the complete GLP-1R and G-proteins (Figure 2, PDB ID 7rgp , Sun et al., 2022) shows some hydrophobic and some specific polar interactions between the peptidic drug and the GLP-1 receptor molecule
