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Recent studies point to alterations in estrogen signaling, including predominance of Estrogen Receptor beta (ER) over Estrogen Receptor alpha (ER), as well as intracrine estradiol production mediated by aromatase and 17-Hydroxysteroid Dehydrogenase (17-HSD), which play a central role in lipedematous adipose tissue dysfunction [12,13,14]

Common side effects may include nausea, diarrhea, and abdominal discomfort

Pre-existing gastrointestinal disease, impaired kidney function, dehydration, and advanced age can prolong or worsen side effects

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After adaptation, it becomes a powerful advantage for weight loss and may actually support higher energy levels than pure GLP-1 agonists achieve