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Its not listed as one of the major side effects like nausea or fatigue, but in practiceespecially with GLP-1 meds like tirzepatide (Mounjaro, Zepbound)mood changes do come up

Diarrhea and constipation can both occur, sometimes alternating

This measure assesses two primary domains: the physical composite (7 items) and the psychosocial composite (13 items)

The peptide is further modified with a fatty diacid moiety (via a linker), which is commonly evaluated in research on peptide stability, distribution behavior, and extended exposure profiles

N Engl J Med (2022) 387:20516

Furthermore, as your body burns through stored glycogen (the way your body stores sugar) during the initial phases of weight loss, it releases a significant amount of water