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The analysis, which included several of the above-mentioned, demonstrated a 14% reduction in the relative risk (RR) of MACE with GLP-1 RAs compared to placebo (87)
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Benefits Beyond Weight Loss: Metabolic and Cardiovascular Health Cardiovascular risk reduction semaglutide reduced major cardiovascular events by 20% in the SELECT trial Blood sugar control significant HbA1c reductions in patients with type 2 diabetes or prediabetes Reduced liver fat growing evidence supports GLP-1 therapy for NAFLD and MASLD Sleep apnea improvement tirzepatide demonstrated 63% reduction in apnea-hypopnea index (2024 NEJM trial) Fatty Liver Disease & GLP-1 Therapy Patients with NAFLD/MASLD may see significant improvement with GLP-1 treatment
To date there have been no systematic reviews on the safety of GLP-1 agonists and/or SGLT2 inhibitors during pregnancy or lactation
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The effects of dose and duration were similar in trials for diabetes
