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doi: 10.1038/s41572-020-0149-1

Most people regain weight within weeks to months if they discontinue use without maintaining lifestyle changes, because the underlying metabolic and appetite pathways return to their baseline state

We excluded patients with cirrhotic liver, history of gall bladder, biliary disorders, pancreatic diseases, interrupted use of GLP-1RAs throughout the study period, and patients used other drugs with potential effects on the motility of biliary tracts such as cholecystokinin, motilin hormone, cholinomimetic agents like prostigmine, erythromycin, cisapride, cholystyramine, intravenous aminoacids, cholinergic agents like atropine, somatostatin, and progesterone, trimebutine, loperamide and ondansetron

The gastrointestinal side effects commonly associated with GLP-1 agonistsincluding nausea, vomiting, and diarrhoeacan lead to fluid depletion

This approach supports sustainable lifestyle changes, improving outcomes while reducing reliance on medications. Digital Twin Care Platform Proven to Shorten GLP-1 Use and Improve Health Twin Health is proven to help patients safely eliminate high-cost medications and sustain weight loss by addressing the underlying causes of metabolic disease

The majority of respondents said they could afford to spend $100 or less per month on a GLP-1 medication, with nearly one-quarter capping out at $50 or less